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Guest Binding Drives Reversible Atropisomerism in Cavitand Hosts

✍ Scribed by Thanh V. Nguyen; David J. Sinclair; Anthony C. Willis; Michael S. Sherburn

Publisher
John Wiley and Sons
Year
2009
Tongue
English
Weight
351 KB
Volume
15
Category
Article
ISSN
0947-6539

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✦ Synopsis

Abstract

Guest‐love‐ometer: The equilibrium inside–outside atropisomeric ratio of ortho‐substituted phenyl cavitands shows a strong solvent dependence. The competition between the ortho‐substituent and the solvent guest for the bowl cavity leads to a sensitive system for the measurement of relative guest binding affinities.magnified image

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