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GUANIDINE COMPOUNDS. II. PREPARATION OF MONO- AND N,N-DI-ALKYLGUANIDINES

โœ Scribed by Bannard, R. A. B.; Casselman, A. A.; Cockburn, W. F.; Brown, G. M.


Book ID
115477072
Publisher
NRC Research Press
Year
1958
Tongue
French
Weight
489 KB
Volume
36
Category
Article
ISSN
0008-4042

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Reactions of a-amino acids with ketones under hydrogenation conditions using 20% Pd(OH) 2 /C as the catalyst gave N-mono-alkylated amino acids in high yields. Reductive methylation of N-mono-alkylated amino acids under the same hydrogenation conditions at 50ยฐC afforded N,N-di-alkylated amino acids i