## Abstract Glutathione SβTransferases (GSTs) are a family of phase II enzymes involved in the detoxification of potential carcinogens and provided of a strong antioxidant function by neutralizing electrophiles and free radicals. The __GSTM1__ and __GSTT1__ isoenzymes exhibit deletion polymorphisms
GSTT1 and GSTM1 allelic polymorphisms in head and neck cancer patients from Italian Lazio Region
β Scribed by Ettore Capoluongo; Giovanni Almadori; Paola Concolino; Francesco Bussu; Concetta Santonocito; Francesca Vendittelli; Jacopo Galli; Cecilia Zuppi; Franco Ameglio; Gaetano Paludetti; Bruno Giardina
- Book ID
- 116347380
- Publisher
- Elsevier Science
- Year
- 2007
- Tongue
- English
- Weight
- 274 KB
- Volume
- 376
- Category
- Article
- ISSN
- 0009-8981
No coin nor oath required. For personal study only.
π SIMILAR VOLUMES
## Abstract ## Background. Alcohol intake and tobacco smoke, in addition to other environmental and genetic factors, have been associated with head and neck cancer. We evaluated the role of metabolic enzyme polymorphisms on the risk of head and neck cancer in a hospitalβbased caseβcontrol study.
## Abstract __Background__. Glutathione Sβtransferase T1 detoxifies some environmental carcinogens while activating others and is deleted in 15% to 38% of humans. We sought to determine whether GSTT1 genotype and genotypes of several related genes are associated with risk of squamous cell carcinoma