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GSTP1 Promoter Methylation is Associated with Recurrence in Early Stage Prostate Cancer

✍ Scribed by Maldonado, Leonel; Brait, Mariana; Loyo, Myriam; Sullenberger, Lauren; Wang, Kevin; Peskoe, Sarah B.; Rosenbaum, Eli; Howard, Roslyn; Toubaji, Antoun; Albadine, Roula; Netto, George J.; Hoque, Mohammad O.; Platz, Elizabeth A.; Sidransky, David

Book ID
122257465
Publisher
Lippincott Williams and Wilkins
Year
2014
Tongue
English
Weight
208 KB
Volume
192
Category
Article
ISSN
0022-5347

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Chromatin changes on the GSTP1 promoter
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✍ Steven T. Okino; Deepa Pookot; Shahana Majid; Hong Zhao; Long-Cheng Li; Robert F πŸ“‚ Article πŸ“… 2007 πŸ› John Wiley and Sons 🌐 English βš– 399 KB

## Abstract Glutathione‐__S__‐transferases (GSTs) are metabolic enzymes that help detoxify and eliminate harmful chemicals. In prostate tumors, expression of GST Ο€ (encoded by __GSTP1__) is frequently lost because of promoter hypermethylation. Here we analyze the native __GSTP1__ promoter in cancer