Growth Regulatory Effects of Cyclic AMP and Polyamine Depletion Are Dissociable in Cultured Mouse Lymphoma Cells
β Scribed by Lisa C. McConlogue, Laurence J. Marton and Philip Coffino
- Book ID
- 124787567
- Publisher
- Rockefeller University Press.
- Year
- 1983
- Tongue
- English
- Weight
- 273 KB
- Volume
- 96
- Category
- Article
- ISSN
- 0021-9525
- DOI
- 10.2307/1610204
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S49.1 Lymphoma cells were arrested in GI phase of the cell cycle when treated with either 1 pM dexamethasone (Dex) or 0.5 mM N6,02-dibutyryl cyclic adenosine 3':5'-monophosphate (Bt,cAMP) plus 0.2 mM theophylline. However, the two agents had markedly different effects on aspects of polyamine and cyc
Intact S49 mouse lymphoma cells were used as a model system to study the effects of cyclic AMP (CAMP) and its analogs on the phosphorylation of regulatory (R) subunit of type I CAMP-dependent protein kinase. Phosphorylation of R subunit was negligible in mutants deficient in adenylate cyclase; low l