✦ LIBER ✦

Growth of mammary epithelial cells in breast-cancer biopsies correlates with egf binding

✍ Scribed by Eva Spitzer; Richard Grosse; Dieter Kunde; H. Eberhard Schmidt

Publisher: John Wiley and Sons
Year: 1987
Tongue: French
Weight: 700 KB
Volume: 39
Category: Article
ISSN: 0020-7136
DOI: 10.1002/ijc.2910390302

No coin nor oath required. For personal study only.

✦ Synopsis

In order to understand the role of EGF in the development of human mammary epithelial tissue, we analysed the binding of I2'1-EGF to sections of breast cancer biopsies. A mean specific '251-EGF binding of 8.9 fmol per mg protein was estimated in thin sections of 17 breast cancer biopsies. Microautoradiographic analysis of '2si-EGF binding to the tissue sections was applied to demonstrate that EGF was bound predominantly to mammary epithelial cells. The binding was clearly correlated to the number of mitoses of mammary epithelial cells in the same samples. The highest EGF binding and proliferation rates were found in biopsies from breast cancer with axillary lymph-node metastases. 4To whom reprint requests should be addressed.

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