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Growth medium-dependent ERK1/2 and AP-1 activity in cultured normal human keratinocytes modulates 1α,25-dihydroxyvitamin D3-induced differentiation

✍ Scribed by Claus Johansen; Knud Kragballe; Lars Iversen


Publisher
Springer-Verlag
Year
2003
Tongue
English
Weight
205 KB
Volume
295
Category
Article
ISSN
0340-3696

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la,25-Dihydroxyvitarnin D3 (10-l2 M to M) caused a dose dependent increase in PKC activity in the solubilized membrane fractions of cultured human keratinocytes and in the cytosolic fractions of cultured human fibroblasts. Maximum activity was induced by 1 a,25-dihydroxyvitamin D3 at 24 h. Sphingosi