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Growth inhibitory effect of transforming growth factor-type beta (TGF-beta) on cultured human keratinocytes

✍ Scribed by Matsumoto, K.; Higashiyama, M.; Kobayashi, Y.; Hashimoto, K.; Nishida, Y.; Yoshikawa, K.


Book ID
123389543
Publisher
Elsevier Science
Year
1990
Tongue
English
Weight
128 KB
Volume
1
Category
Article
ISSN
0923-1811

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TGF-beta is a potent inhibitor of EGF-induced DNA synthesis in primary rat hepatocyte cultures. Norepinephrine (NE) was shown to modulate this inhibition of DNA synthesis. It produced a five-fold increase, from 2.8 pM to 14.4 pM, in the IDSo for TGF-beta. The effect was dose-dependent and was signif