Growth inhibition of ovarian cancer cells induced by antisense IL-6 oligonucleotide-mediated IL-6 translation arrest
✍ Scribed by J.M. Watson; J.S. Berek; Martínez-Maza
- Book ID
- 119054257
- Publisher
- Elsevier Science
- Year
- 1992
- Tongue
- English
- Weight
- 149 KB
- Volume
- 45
- Category
- Article
- ISSN
- 0090-8258
No coin nor oath required. For personal study only.
📜 SIMILAR VOLUMES
## BACKGROUND. In prostate cancer, we and others have observed distinct phenotypic responses to interleukin-6 (IL-6), which acts either as a paracrine growth inhibitor in the LNCaP cell line or as an autocrine growth stimulator in PC-3, DU145, and TSU cell lines. To understand the underlying mechan
Interleukin-6 (IL-6) belongs to a family of cytokines that use receptors consisting of a common signal-transducing chain (gp130). Baf/3 cells transfected with the human IL-6 receptor (IL-6R) and gp130 (Baf/3-gp130/IL-6R) can only grow in medium containing IL-6. We attempted to interrupt the signal t