Growth inhibition and induction of phenotypic alterations in MCF-7 breast cancer cells by an IMP dehydrogenase inhibitor
β Scribed by Sidi, Y; Panet, C; Wasserman, L; Cyjon, A; Novogrodsky, A; Nordenberg, J
- Book ID
- 109835956
- Publisher
- Nature Publishing Group
- Year
- 1988
- Tongue
- English
- Weight
- 627 KB
- Volume
- 58
- Category
- Article
- ISSN
- 0007-0920
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## Abstract 1Ξ±,25βDihydroxyvitamin D~3~ [1Ξ±,25(OH)~2~D~3~], the hormonally active form of vitamin D~3~, has been shown to be a potent negative growth regulator of breast cancer cells both in vitro and in vivo. 1Ξ±,25(OH)~2~D~3~ acts through two different mechanisms. In addition to regulating gene tr