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Growth inhibition and induction of phenotypic alterations in MCF-7 breast cancer cells by an IMP dehydrogenase inhibitor

✍ Scribed by Sidi, Y; Panet, C; Wasserman, L; Cyjon, A; Novogrodsky, A; Nordenberg, J


Book ID
109835956
Publisher
Nature Publishing Group
Year
1988
Tongue
English
Weight
627 KB
Volume
58
Category
Article
ISSN
0007-0920

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## Abstract 1Ξ±,25‐Dihydroxyvitamin D~3~ [1Ξ±,25(OH)~2~D~3~], the hormonally active form of vitamin D~3~, has been shown to be a potent negative growth regulator of breast cancer cells both in vitro and in vivo. 1Ξ±,25(OH)~2~D~3~ acts through two different mechanisms. In addition to regulating gene tr