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Parallel inhibition of cell growth and induction of cell migration and invasion in breast cancer cells by bone morphogenetic protein 4

✍ Scribed by Johanna M. Ketolainen; Emma-Leena Alarmo; Vilppu J. Tuominen; Anne Kallioniemi

Publisher
Springer US
Year
2010
Tongue
English
Weight
527 KB
Volume
124
Category
Article
ISSN
0167-6806

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Expression of bone morphogenetic protein
Expression of bone morphogenetic protein 6 in normal mammary tissue and breast cancer cell lines and its regulation by epidermal growth factor
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Bone morphogenetic proteins (BMPs) are multifunctional regulators of proliferation, differentiation and apoptosis. BMP-6 is involved in numerous developmental processes. We have demonstrated expression of BMP-6 in breast cancer cell lines by RT-PCR and immuno-histochemistry. The level of BMP-6 mRNA