𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Growth hormone effects on RNA and protein synthesis in liver

✍ Scribed by Korner, Asher

Publisher
Wiley (John Wiley & Sons)
Year
1965
Tongue
English
Weight
919 KB
Volume
66
Category
Article
ISSN
0095-9898

No coin nor oath required. For personal study only.

✦ Synopsis

The case for believing that growth hormone exerts its protein anabolic action by stimulating messenger RNA synthesis is summarized. Ribosomes, but not polysomes, from liver of rats have amino acid incorporating abilities in vitro which are directIy related to the level of circulating growth hormone in the rat. Growth hormone treatment of rats stimulates labeling of all types of RNA including mRNA, possibly by activating the liver RNA polymerase. Growth hormone can exert some of its stimulating activity even in actinomycin-treated rats. It is argued that control of rate, as opposed to type, of protein synthesized would be more likely to be exercised at the cytoplasmic rather than the genetic level, and anomalous results are examined in light of this suggestion.

πŸ“œ SIMILAR VOLUMES

Decreased expression of the growth hormo
Decreased expression of the growth hormone receptor and growth hormone binding protein in rat liver nodules
✍ Agneta Levinovitz; Bolette Husman; Lennart C. Eriksson; Gunnar Norstedt; GΓΆran A πŸ“‚ Article πŸ“… 1990 πŸ› John Wiley and Sons 🌐 English βš– 742 KB

## Abstract The growth hormone receptor (GHR) and growth hormone‐binding protein (GH‐BP) expression were characterized in liver nodules and hepatomas from male Wistar rats. The mRNA levels of GHR and GH‐BP, studied by northern blot analysis and solution hybridization, were 35–50% (in nodules) and 2

Effects of prolactin and growth hormone
Effects of prolactin and growth hormone on protein synthesis in larval and adult frogs (Rana pipiens)
✍ Snyder, Benjamin W. ;Frye, B. E. πŸ“‚ Article πŸ“… 1974 πŸ› John Wiley and Sons 🌐 English βš– 495 KB πŸ‘ 1 views

## Abstract Frogs and tadpoles (__Rana pipiens__) were treated with mammalian prolactin or growth hormone for several days, then injected with ^14^C‐leucine. Fourteen to sixteen hours later the animals were killed and the amount of label incorporated into protein of muscle, liver, and gut was measu

Hepatic growth hormone receptor, insulin
Hepatic growth hormone receptor, insulin-like growth factor I, and insulin-like growth factor-binding protein messenger RNA expression in pediatric liver disease
✍ R I Holt; P A Crossey; J S Jones; A J Baker; B Portmann; J P Miell πŸ“‚ Article πŸ“… 1997 πŸ› John Wiley and Sons 🌐 English βš– 331 KB πŸ‘ 1 views

## Major changes in serum levels of insulin-like growth factor After secretion from the anterior pituitary gland, growth hormone (GH) binds to specific cell-surface receptors I (IGF-I) and IGF-binding proteins (IGFBPs) occur in children with end-stage liver disease in association with changes in (

Effects of dioxane on RNA synthesis in t
Effects of dioxane on RNA synthesis in the rat liver
✍ Rabinder N. Kurl; Lorenz Poellinger; Johan Lund; Jan-Γ…ke Gustafsson πŸ“‚ Article πŸ“… 1981 πŸ› Springer-Verlag 🌐 English βš– 235 KB

The effect of dioxane on transcription was investigated. On intravenous administration of the lower dose (10 mg/rat) both RNA polymerase A and B activities were initially depressed but recovered after i h. A secondary effect on RNA polymerase A was observed but the enzyme activity recovered at 24 h