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Effects of dioxane on RNA synthesis in the rat liver

✍ Scribed by Rabinder N. Kurl; Lorenz Poellinger; Johan Lund; Jan-Åke Gustafsson

Publisher
Springer-Verlag
Year
1981
Tongue
English
Weight
235 KB
Volume
49
Category
Article
ISSN
0340-5761

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✦ Synopsis

The effect of dioxane on transcription was investigated. On intravenous administration of the lower dose (10 mg/rat) both RNA polymerase A and B activities were initially depressed but recovered after i h. A secondary effect on RNA polymerase A was observed but the enzyme activity recovered at 24 h when it was about 35% above control values whereas RNA polymerase B activity had achieved control values. With a higher dose (100 mg/rat) the pattern was similar but the suppressive effects were more pronounced -RNA polymerase B activity never attained control values during the times studied whereas there was no increase in RNA polymerase A activity at 24 h.

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