✦ LIBER ✦

Growth factors and bladder cancer: Clinical implications of the interactions between growth factors and their urothelial receptors

✍ Scribed by Dr. Edward M. Messing

Publisher: John Wiley and Sons
Year: 1992
Tongue: English
Weight: 910 KB
Volume: 8
Category: Article
ISSN: 8756-0437
DOI: 10.1002/ssu.2980080507

No coin nor oath required. For personal study only.

✦ Synopsis

Growth factors (GFs) are a class of proteins that bind to specific cell surface receptors (GF-Rs), inducing a variety of responses including mitosis, in susceptible target cells. Abnormal production, expression, and/or function of GFs or GF-Rs can result in unregulated growth, the hallmark of malignant transformation. This chapter reviews those GFs/GF-Rs that have been linked to human bladder cancer. It focuses particularly on one [epidermal growth factor (EGF), which is excreted in urine in high concentrations] and its possible role in the development and growth of urothelial malignancy. Potential clinical applications in diagnosis, staging, prevention, and treatment are discussed.

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