## Abstract Overexpressed epidermal growth receptor factor receptors (EGFRs) are thought to contribute to the malignant phenotype of human glioblastomas (GBMs), but the mechanism is not well understood. We found that SKMG‐3 cells, a rare GBM cell line that maintains EGFR gene amplification __in vit
✦ LIBER ✦
Growth factor receptors signaling in glioblastoma cells: therapeutic implications
✍ Scribed by Mia Carapancea; Oana Alexandru; Ani S. Fetea; Laura Dragutescu; Juan Castro; Ada Georgescu; A. Popa-Wagner; Magnus L. Bäcklund; Rolf Lewensohn; Anica Dricu
- Publisher
- Springer US
- Year
- 2008
- Tongue
- English
- Weight
- 453 KB
- Volume
- 92
- Category
- Article
- ISSN
- 0167-594X
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## Abstract In __de novo__ glioblastoma multiforme, loss of the tumour suppressor protein PTEN can coincide with the expression of a naturally occurring mutant epidermal growth factor receptor known as ΔEGFR. ΔEGFR signals constitutively via the phosphatidylinositol 3‐kinase (PI3K)/protein kinase A