Glioblastoma cell growth is suppressed by disruption of fibroblast growth factor pathway signaling
β Scribed by Watcharin Loilome; Avadhut D. Joshi; Colette M. J. ap Rhys; Sara Piccirillo; Vescovi L. Angelo; Gary L. Gallia; Gregory J. Riggins
- Publisher
- Springer US
- Year
- 2009
- Tongue
- English
- Weight
- 360 KB
- Volume
- 94
- Category
- Article
- ISSN
- 0167-594X
No coin nor oath required. For personal study only.
π SIMILAR VOLUMES
Astrocytes exhibit significant changes in fibroblast growth factor receptor (FGFR) gene expression during malignant progression. These changes include induction of FGFR1 and concomitant loss of FGFR2 expression. The induction of FGFR1 is believed to endow malignant astrocytes with a selective growth
## Abstract Overexpressed epidermal growth receptor factor receptors (EGFRs) are thought to contribute to the malignant phenotype of human glioblastomas (GBMs), but the mechanism is not well understood. We found that SKMGβ3 cells, a rare GBM cell line that maintains EGFR gene amplification __in vit
Basic fibroblast growth factor (bFGF) is found in a variety of cells and tissues. We have previously shown that bFGF is a transforming growth factor, but only when fused to a signal peptide (sp-bFGF). Cells expressing the native bFGF are tumorigenic in nude mice only, where the tumors form at a low
## Abstract A cell growth factor protein (insulin) and/or a cellβadhesion protein (fibronectin) were immobilized on surfaceβhydrolyzed poly(methyl methacrylate) membranes. The growth of mouse fibroblast cells STO was accelerated by the immobilized insulin. This acceleration was enhanced by introduc