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Growth factor-like effect of urokinase type plasminogen activator in human renal cells

✍ Scribed by Ci-Jiang He; Jean-Michel Rebibou; Marie-Noëlle Peraldi; Quentin Meulders; Eric Rondeau

Book ID
115763889
Publisher
Elsevier Science
Year
1991
Tongue
English
Weight
586 KB
Volume
176
Category
Article
ISSN
0006-291X

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## Abstract Urokinase‐type plasminogen activator (uPA) binds to its receptor, uPAR, on the surface of cancer cells, leading to the formation of plasmin. Rhabdomyosarcoma (RMS) cell lines secrete high levels of insulin‐like growth factor II (IGF‐II), suggesting autocrine IGFs play a major role in th