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Growth factor enhanced retroviral gene transfer to the adult central nervous system

โœ Scribed by King, L A; Mitrophanous, K A; Clark, L A; Kim, V N; Rohll, J B; Kingsman, A J; Colello, R J


Book ID
110038693
Publisher
Nature Publishing Group
Year
2000
Tongue
English
Weight
395 KB
Volume
7
Category
Article
ISSN
0969-7128

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Background Canavan disease (CD) is an autosomal recessive leukodystrophy characterized by deยฎciency of aspartoacylase (ASPA) and increased levels of N-acetylaspartic acid (NAA) in brain and body ยฏuids, severe mental retardation and early death. Gene therapy has been attempted in a number of children