Growth Control in a Human Colon Carcinoma Cell Line Mediated by Cell-Associated Transforming Growth Factor-α (TGFα)
✍ Scribed by Mark A. Zorbas; Lynn C. Yeoman
- Book ID
- 115601459
- Publisher
- Elsevier Science
- Year
- 1993
- Tongue
- English
- Weight
- 615 KB
- Volume
- 206
- Category
- Article
- ISSN
- 0014-4827
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Antibodies to epidermal-growth-factor receptor (EGF) and transforming growth factor-a (TGVa) were used to determine the role of endogenous TGF-a in the growth of 2 human colon-carcinoma cell lines. Both the GEO and HCT I 16 coloncarcinoma cell lines secrete similar levels of TGF-a and have similar n
Transforming growth factor-␣ (TGF-␣) is synthesized as a membrane-bound precursor protein, pro-TGF-␣, that is converted to a soluble form by 2 endoproteolytic cleavages. Several factors have been implicated in the regulation of the second rate-limiting step, including protein kinase C (PKC). Earlier