Group-specific component (Gc) subtypes in the Chinese population of Hong Kong
โ Scribed by Kim Y. Y. Kwok; W. H. P. Lewis
- Publisher
- Springer
- Year
- 1981
- Tongue
- English
- Weight
- 317 KB
- Volume
- 59
- Category
- Article
- ISSN
- 0340-6717
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โฆ Synopsis
The distribution of Gc subtypes in a sample of the Chinese population of Hong Kong was studied using isoelectric focusing followed by immunofixation. A sensitive modification of this technique is described. Nine distinct phenotypes were observed which appear to result from the three common alleles Gc1F, Gc1S, and Gc2, which are found in most populations. The respective gene frequencies were 0.494, 0.258, and 0.247. In addition, two rare phenotypes were observed which appear to be due to a rare allele tentatively identified as Gc2C2.
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DNA specimens isolated from the blood samples of 209 unrelated Chinese persons were characterised with four probes, i.e. MS1 (D1S7), YNH24 (D2S44), pH30 (D4S139) and TBQ7 (D10S28), in conjunction with the restriction enzyme HaeIII to establish a population DNA-profile database. Each locus showed a f
The group-specific component (Gc) was examined in a sample of 78 chimpanzees (Pan troglodytes). With isoelectric focusing followed by immunofixation, two different phenotypes are observed. They both differ from the Gc types observed in man. Two alleles are postulated, one coding for a double-band co