✦ LIBER ✦

Group selective reduction of acetals related to the ansa chain of the streptovaricins: Conformational and stereochemical analysis

✍ Scribed by Stuart L. Schreiber; Zhaoyin Wang; Gayle Schulte

Book ID: 104216578
Publisher: Elsevier Science
Year: 1988
Tongue: French
Weight: 263 KB
Volume: 29
Category: Article
ISSN: 0040-4039
DOI: 10.1016/s0040-4039(00)80423-2

No coin nor oath required. For personal study only.

✦ Synopsis

The group selective reductive cleavage of benzylidene acetals derived from dials containing chains equipped with a central chirotopic, nonstereogenic carbon atom is reported. The stereochemistry that is obtained at the central carbon is suitable for application to the synthesis of members of the streptovaricin class of antibiotics.

📜 SIMILAR VOLUMES

Selective reduction of the ester group i

Selective reduction of the ester group in the 1,3-dithiol-2-(thi)one and tetrathiafulvalene series. Access to the related phosphonium salts and their Wittig reactions

✍ Nozdryn, T.; Clemenceau, D.; Cousseau, J.; Morisson, V.; Gorgues, A.; Orduna, J. 📂 Article 📅 1993 🏛 Elsevier Science 🌐 English ⚖ 164 KB

Glycerol’s influence on the oxidized ins

Glycerol’s influence on the oxidized insulin B-chain conformation in relation to the selectivity variation of subtilisin: an nuclear magnetic resonance and simulated annealing study

✍ François-Yves Dupradeau; Guillaume Le Flem; Jean-Michel Wieruszeski; Miguel Cali 📂 Article 📅 1999 🏛 Elsevier Science 🌐 English ⚖ 455 KB

Conformational analysis of HIV protease

Conformational analysis of HIV protease inhibitors. I. Rotation of the amide group adjacent to the P′1 decahydroisoquinoline ring system in ro 31-8959 and related systems

✍ Mark A. Murcko; B. Govinda Rao 📂 Article 📅 1993 🏛 John Wiley and Sons 🌐 English ⚖ 719 KB

Pipecolic acid derivatives have proven to be effective Pi groups in a series of highly potent inhibitors of the enzyme HIV protease. One such inhibitor, Ro 31-8959, contains the saturated bicyclic ring system decahydroisoquinoline (DIQ) in the Pi position. The binding orientation of Ro 31-8959 is kn