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Green and efficient synthesis of pyrazolo[3,4-b]quinolin-5-ones derivatives by microwave-assisted multicomponent reaction in hot water medium

✍ Scribed by Anastasiya Yu. Andriushchenko; Sergey M. Desenko; Vitaliy N. Chernenko; Valentin A. Chebanov

Publisher
Journal of Heterocyclic Chemistry
Year
2010
Tongue
English
Weight
89 KB
Volume
48
Category
Article
ISSN
0022-152X

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✦ Synopsis

Abstract

Novel simple, efficient, and eco‐friendly synthetic procedure for preparation of pyrazolo[3,4‐b]quinolin‐5‐ones based on three‐component microwaves‐assisted heterocyclization reaction of 5‐aminopyrazoles, aromatic aldehydes, and dimedone in hot‐water medium was developed. The new method allows obtaining target heterocycles in good and excellent yields and with high degree of purity. J. Heterocyclic Chem., (2011).

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## Abstract magnified image A series of furo[3,4‐__e__]pyrazolo[3,4‐__b__]pyridine analogues of podophylloxin were synthesized __via__ three‐component reactions of aldehydes, 3‐methyl‐1‐phenyl‐1__H__‐pyrazol‐5‐amine and tetronic acid in water under microwave irradiation without catalyst. This effi