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Grapefruit Juice Reduces the Oral Bioavailability of Fexofenadine But Not Desloratadine

✍ Scribed by Dr Christopher Banfield, Samir Gupta, Mark Marino, Josephine Lim, Melton Affrime

Book ID: 119926408
Publisher: Springer International Publishing AG
Year: 2002
Tongue: English
Weight: 146 KB
Volume: 41
Category: Article
ISSN: 0312-5963
DOI: 10.2165/00003088-200241040-00004

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Fexofenadine has been identified as a substrate for both the efflux transporter, P-glycoprotein (P-gp), as well as the influx transporter, organic anion transporting polypeptide (OATP). Clinical studies in humans showed that fruit juices reduced the oral bioavailability of fexofenadine by preferenti

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