Granulocyte transfusions in children using filter-collected cells

✍ Scribed by Donald J. Higby; Arnold Freeman; Edward S. Henderson; Lucius Sinks; Elias Cohen

• Book ID: 102664298
• Publisher: John Wiley and Sons
• Year: 1976
• Tongue: English
• Weight: 550 KB
• Volume: 38
• Category: Article
• ISSN: 0008-543X
• DOI: 10.1002/1097-0142(197609)38:3<1407::aid-cncr2820380347>3.0.co;2-s

✦ Synopsis

Twenty-three children with various stages and morphologic types of leukemia were treated with multiple granulocyte transfusions obtained by filtration leukapheresis when neutropenia-associated infection appeared unresponsive to antibiotics. All children meeting the above qualifications were given granulocyte transfusions during this time period. Twenty-one of 23 became afebrile during or shortly after the transfusions; one died with disseminated Herpes simplex; and one became well enough to be discharged, although he was never free of fever. Frequent mild to moderate fever and chills were noted. One child developed a severe pulmonary reaction followed by resolution of pneumonia. Filtration leukapheresis is a useful adjunct in controlling severe infections in neutropenic children.