Granulocyte-macrophage colony-stimulating factor in acute non-lymphocytic leukemia before and after chemotherapy
β Scribed by G. Visani; D. Damiani; A. Cenacchi; D. Russo; G. Revignas; B. Gamberi; R. Fanin; M. Fogli; M. Baccarani; S. Tura
- Publisher
- Springer
- Year
- 1991
- Tongue
- English
- Weight
- 589 KB
- Volume
- 63
- Category
- Article
- ISSN
- 0939-5555
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Background. Intensification chemotherapy improves the prognosis for children with acute lymphoblastic leukemia (ALL), but results in considerable morbidity, primarily due to myelosuppression with resultant neutropenia. Recombinant granulocyte colony-stimulating factor (G-CSF) shortens neutropenia fo
Expression of granulocyte colony-stimulating factor (G-CSF) receptor (G-CSFR) and in vitro proliferative response to G-CSF were investigated by quantitative immunofluorescence and [ 3 H] thymidine uptake, respectively, in a series of acute myeloid leukemias (AML). The results indicated that G-CSFR w
GM-CSF is a major regulator of myelopoiesis. Recombinant human GM-CSF (250 micrograms/m2 per day i.v.) was used prior to chemotherapy ("3 + 7" scheme) to recruit leukemic blasts in vivo (de novo AML patients, n = 20) into the chemotherapy sensitive phases of the cell cycle. The stimulatory effect of
## Background: Our purpose was to increase the dose intensity of chemotherapy and reduce the days with neutropenic fever in childhood high-risk (hr) acute lymphoblastic leukemia (all) by systematic use of granulocyte-macrophage colony-stimulating factor (gm-csf). ## Procedure: All children with h