## Background: Our purpose was to increase the dose intensity of chemotherapy and reduce the days with neutropenic fever in childhood high-risk (hr) acute lymphoblastic leukemia (all) by systematic use of granulocyte-macrophage colony-stimulating factor (gm-csf). ## Procedure: All children with h
Granulocyte colony-stimulating factor supportive treatment following intensive chemotherapy in acute lymphocytic leukemia in first remission
โ Scribed by Hagop M. Kantarjian; Elihu Estey; Susan O'Brien; Elias Anaissie; Miloslav Beran; Sherry Pierce; Lester Robertson; Michael J. Keating
- Publisher
- John Wiley and Sons
- Year
- 1993
- Tongue
- English
- Weight
- 503 KB
- Volume
- 72
- Category
- Article
- ISSN
- 0008-543X
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๐ SIMILAR VOLUMES
GM-CSF is a major regulator of myelopoiesis. Recombinant human GM-CSF (250 micrograms/m2 per day i.v.) was used prior to chemotherapy ("3 + 7" scheme) to recruit leukemic blasts in vivo (de novo AML patients, n = 20) into the chemotherapy sensitive phases of the cell cycle. The stimulatory effect of
## Abstract As sensitization of leukemic cells with granulocyte colonyโstimulating factor (Gโcsf) can enhance the cytotoxicity of chemotherapy in acute myeloid leukemia (AML), a pilot study was conducted in order to evaluate the effect of Gโcsf priming combined with lowโdose chemotherapy in patient