Treatment of de novo acute myelogenous l
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Valent, Peter ;Sillaber, Christian ;Geissler, Klaus ;Andreeff, Michael ;Tafuri,
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Article
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1992
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John Wiley and Sons
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English
⚖ 418 KB
GM-CSF is a major regulator of myelopoiesis. Recombinant human GM-CSF (250 micrograms/m2 per day i.v.) was used prior to chemotherapy ("3 + 7" scheme) to recruit leukemic blasts in vivo (de novo AML patients, n = 20) into the chemotherapy sensitive phases of the cell cycle. The stimulatory effect of