j774A. 1 immortalized macrophage tumor cells display several phenotypes and functional capacities similar to that of murinc peritoneal exudate macrophages (PEM). Both populations display comparable number of M-CSF receptors. Yet the number of GM-CSF receptors on J774A.1 cells is only one-fourth that
Granulocyte-macrophage colony-stimulating factor (GM-CSF) and T-cell responses: what we do and don't know
โ Scribed by Shi, Yufang; Liu, Catherine H; Roberts, Arthur I; Das, Jyoti; Xu, Guangwu; Ren, Guangwen; Zhang, Yingyu; Zhang, Liying; Yuan, Zeng Rong; Tan, Hung Sheng William
- Book ID
- 110020720
- Publisher
- Nature Publishing Group
- Year
- 2006
- Tongue
- English
- Weight
- 424 KB
- Volume
- 16
- Category
- Article
- ISSN
- 0007-0610
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๐ SIMILAR VOLUMES
## Abstract Secretion of a granulocyteโmacrophage colonyโstimulating factor (GMโCSF) was accomplished by LโP3 cells in culture with a serumโfree medium. Cell proliferation per se was not requisite for the production of GMโCSF; the cells continued secreting GMโCSF even after their growth had been su
To clarify the mechanism of eosinophilia in adult T-cell leukemia (ATL), we studied three ATL patients having marked eosinophilia. Eosinophil-predominant colony-stimulating activity was detected in the serum of one patient and in the conditioned media (CM) from cultured ATL cells from two patients.