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Granulocyte colony-stimulating factor and interleukin-6-producing lung cancer cell line, LCAM

โœ Scribed by Inoue, Masayoshi; Minami, Masato; Fujii, Yoshitaka; Matsuda, Hikaru; Shirakura, Ryota; Kido, Tetsuo

Publisher
John Wiley and Sons
Year
1997
Tongue
English
Weight
391 KB
Volume
64
Category
Article
ISSN
0022-4790

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โœฆ Synopsis

Background and objectives:

We describe a case of granulocyte colony-stimulating factor (gcsf) and interleukin-6 (il-6)-producing lung cancer.

Methods:

A 53-year-old man underwent left upper lobectomy under diagnosis of lung cancer. the tumor obtained by a preoperative biopsy was analyzed.

Results:

Preoperative data showed leukocytosis with left-shift of leukocytic morphology and thrombocytosis and an elevated serum gcsf level. histological examination revealed poorly differentiated adenocarcinoma. a cell line, named lcam, was established from the tumor and the cytokines in the culture medium were measured by enzyme immunoassay. gcsf and il-6 were produced in large amounts by lcam, but granulocyte-macrophage colony-stimulating factor (gmcsf) and interleukin-3 (il-3) were not. a proportion of lcam expressed gcsf receptor on the cell surface, but il-6 receptor could not be detected. lcam proliferation was inhibited in the culture with antihuman gcsf antibody in a dose-dependent manner.

Conclusions:

We suggest that lcam proliferation is positively regulated by gcsf.

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