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Gram Scale Synthesis of the Glucuronide Metabolite of ABT-724

โœ Scribed by Engstrom, Kenneth M.; Daanen, Jerome F.; Wagaw, Seble; Stewart, Andrew O.


Book ID
126234759
Publisher
American Chemical Society
Year
2006
Tongue
English
Weight
115 KB
Volume
71
Category
Article
ISSN
0022-3263

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Protected quercetin was first transformed selectively in its 3-O-b-D-glucoside. Further protection of the remaining phenolic hydroxyl group allows a clean oxidation of the glucoside by TEMPO/NaOCl/NaBr under phase transfer conditions into the corresponding glucuronide which was cleanly deprotected t