๐”– Bobbio Scriptorium
โœฆ   LIBER   โœฆ

Gram-positive commensal bacteria for mucosal vaccine delivery

โœ Scribed by Vincent A Fischetti; Donata Medaglini; Gianni Pozzi

Publisher
Elsevier Science
Year
1996
Tongue
English
Weight
757 KB
Volume
7
Category
Article
ISSN
0958-1669

No coin nor oath required. For personal study only.

โœฆ Synopsis

To avoid the use of engineered pathogens for vaccine delivery, systems have been developed that allow the expression of heterologous antigens in commensal Gram-positive bacteria. In some cases, both a serum IgG and secretory IgA response are induced to the recombinant protein after vaccination, verifying the validity of the approach. These live recombinant bacteria may be used in the future to introduce a protective immune response to pathogenic microorganisms after mucosal colonization.

๐Ÿ“œ SIMILAR VOLUMES

Expression of foreign proteins on gram-p
Expression of foreign proteins on gram-positive commensal bacteria for mucosal vaccine delivery
โœ Vincent A. Fischetti; Donata Medaglini; Marco Oggioni; Gianni Pozzi ๐Ÿ“‚ Article ๐Ÿ“… 1993 ๐Ÿ› Elsevier Science ๐ŸŒ English โš– 815 KB

Non-pathogenic Gram-positive oral commensal bacteria expressing recombinant fusion proteins on their cell surface have been successfully used to raise both a mucosal and a systemic immune response to foreign antigens while colonizing the oropharynx. In this system, fusion-protein vaccines are delive

Anthrax vaccine powder formulations for
Anthrax vaccine powder formulations for nasal mucosal delivery
โœ Ge Jiang; Sangeeta B. Joshi; Laura J. Peek; Duane T. Brandau; Juan Huang; Matthe ๐Ÿ“‚ Article ๐Ÿ“… 2006 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 490 KB

Anthrax remains a serious threat worldwide as a bioterror agent. A second-generation anthrax vaccine currently under clinical evaluation consists of a recombinant Protective Antigen (rPA) of Bacillus anthracis. We have previously demonstrated that complete protection against inhalational anthrax can

Rapid method for distinction of gram-neg
Rapid method for distinction of gram-negative from gram-positive bacteria
โœ T. Gregersen ๐Ÿ“‚ Article ๐Ÿ“… 1978 ๐Ÿ› Springer ๐ŸŒ English โš– 211 KB

A rapid method for distinction between gram-negative and grampositive bacteria by means of a 3% solution of potassium hydroxide is tested on 71 gram-positive and 55 gram-negative bacterial strains. The method proved reliable with one exception only, a Bacillus macerans strain. That strain was defina

Studies on the aminopeptidase test for t
Studies on the aminopeptidase test for the distinction of gram-negative from gram-positive bacteria
โœ G. Cerny ๐Ÿ“‚ Article ๐Ÿ“… 1978 ๐Ÿ› Springer ๐ŸŒ English โš– 495 KB

The aminopeptidase test was performed with representatives of gram-negative, gram-positive, and gram-variable bacteria. All gram-negative bacteria tested gave a positive test reaction with L-alanine-4-nitroanilide as test substrate. Representatives of the coryneform bacteria and some streptococci sh