๐”– Bobbio Scriptorium
โœฆ   LIBER   โœฆ

Golfomycin A, a Novel Designed Molecule with DNA-Cleaving Properties and Antitumor Activity

โœ Scribed by K. C. Nicolaou; Golfo Skokotas; S. Furuya; H. Suemune; D. Colette Nicolaou

Publisher
John Wiley and Sons
Year
1990
Tongue
English
Weight
501 KB
Volume
29
Category
Article
ISSN
0044-8249

No coin nor oath required. For personal study only.

โœฆ Synopsis

Fig. 1. Molecular structure of 10 in the crystal (ORTEP) with the thermal ellipsoids at the 10% probability level for the non-hydrogen atoms. The estimated standard deviations are 0.009-0.01 1 A and 0.7-0.8" for bond distances

๐Ÿ“œ SIMILAR VOLUMES

Man-designed bleomycins. synthesis of di
Man-designed bleomycins. synthesis of dioxygen activating molecules and a DNA cleaving molecule based on bleomycin-Fe(II)-02 complex
โœ Atsushi Kittaka; Yuichi Sugano; Masami Otsuka; Masaji Ohno ๐Ÿ“‚ Article ๐Ÿ“… 1988 ๐Ÿ› Elsevier Science ๐ŸŒ French โš– 916 KB

A synthetic model for the metal binding site of bleomycin with a 4-methoxypyridine nucleus and a tert-butyl group is shown to be comparable to bleomycin interms of dioxygen activation. This model ligand is coupled with a DNA affinity moiety, tetrapeptide S, to afford a mandesigned bleomycin which e