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Gold nanoparticle probes for the detection of nucleic acid targets

โœ Scribed by C. Shad Thaxton; Dimitra G. Georganopoulou; Chad A. Mirkin

Book ID
116350296
Publisher
Elsevier Science
Year
2006
Tongue
English
Weight
321 KB
Volume
363
Category
Article
ISSN
0009-8981

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We have constructed light-up probes for nucleic acid detection. The light-up probe is a peptide nucleic acid (PNA) oligonucleotide to which the asymmetric cyanine dye thiazole orange (TO) is tethered. It combines the excellent hybridization properties of PNA and the large fluorescence enhancement of