Synthesis of MRI contrast agents derived
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Mojmír Suchý; Alex X. Li; Robert Bartha; Robert H.E. Hudson
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Article
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2010
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Elsevier Science
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English
⚖ 555 KB
A cell penetrating peptide conjugate and dimeric PARACEST MRI contrast agents, based on the DOTAM-Gly-L-Phe-OH scaffold have been prepared in moderate yields using diethyl azodicarboxylate (DEAD) or iodine-mediated disulfide bridge formation as a key step. Magnetic (PARACEST) properties of these age