✦ LIBER ✦
Synthesis of MRI contrast agents derived from DOTAM-Gly-l-Phe-OH incorporating a disulfide bridge: Conjugation to a cell penetrating peptide and preparation of a dimeric agent
✍ Scribed by Mojmír Suchý; Alex X. Li; Robert Bartha; Robert H.E. Hudson
- Publisher
- Elsevier Science
- Year
- 2010
- Tongue
- English
- Weight
- 555 KB
- Volume
- 20
- Category
- Article
- ISSN
- 0960-894X
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✦ Synopsis
A cell penetrating peptide conjugate and dimeric PARACEST MRI contrast agents, based on the DOTAM-Gly-L-Phe-OH scaffold have been prepared in moderate yields using diethyl azodicarboxylate (DEAD) or iodine-mediated disulfide bridge formation as a key step. Magnetic (PARACEST) properties of these agents have been evaluated.