Glycosaminoglycan accumulation with partial deficiency of β-glucuronidase in the C3H strain of mice

✍ Scribed by Shaul Yatziv; Robert P. Erickson; Robert Sandman; William van B. Robertson

• Book ID: 104784041
• Publisher: Springer
• Year: 1978
• Tongue: English
• Weight: 307 KB
• Volume: 16
• Category: Article
• ISSN: 0006-2928
• DOI: 10.1007/bf00484528

✦ Synopsis

Young (60--80 days) mice of the low beta-glucuronidase strain, C3H/HeJ, showed no differences in hepatic levels of glycosaminoglycans (GAGs) when compared to the randombred, "normal" Swiss-Webster mice of the same age. However, by 12 months of age hepatic GAG is nearly twice as high in C3H/HeJ mice as in Swiss-Webster mice. Studies of beta-glucuronidase, beta-galactosidase, and N-acetyl-beta-glucosaminidase in four tissues of the two types of mice at the two ages revealed that glucuronidase was the only enzyme with lower activity in the C3H/HeJ strain.