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Inbred Strain-Specific Response to Biglycan Deficiency in the Cortical Bone of C57BL6/129 and C3H/He Mice

✍ Scribed by Joseph M Wallace; Kurtulus Golcuk; Michael D Morris; David H Kohn

Book ID: 111485705
Publisher: American Society for Bone and Mineral Research
Year: 2009
Tongue: English
Weight: 821 KB
Volume: 24
Category: Article
ISSN: 0884-0431
DOI: 10.1359/jbmr.081259

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## Abstract C3H/HeJ(C3H) mice are approximately 50‐fold more susceptible to liver‐tumor induction than C57BL/6J(B6) mice. This difference in susceptibility is a consequence of allelic differences in hepatocarcinogen sensitivity(__Hcs__) genes that control the growth of preneoplastic lesions in the