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Glycogen synthase kinase 3β (GSK3β) in tumorigenesis and cancer chemotherapy

✍ Scribed by Jia Luo

Book ID: 116334872
Publisher: Elsevier Science
Year: 2009
Tongue: English
Weight: 195 KB
Volume: 273
Category: Article
ISSN: 0304-3835
DOI: 10.1016/j.canlet.2008.05.045

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## Glycogen synthase kinase-3␤ (GSK-3␤ ) is a multifunctional protein kinase that phosphorylates a variety of substrates including the neuronal-specific microtubuleassociated protein tau. Here we report that the downregulation of the GSK-3␤ protein is an early event in the course of the differenti