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Glycogen synthase kinase-3β binds to E2F1 and regulates its transcriptional activity

✍ Scribed by Gisela García-Alvarez; Verònica Ventura; Oriol Ros; Rosa Aligué; Joan Gil; Albert Tauler

Book ID: 113485998
Publisher: Elsevier Science
Year: 2007
Tongue: English
Weight: 620 KB
Volume: 1773
Category: Article
ISSN: 0167-4889
DOI: 10.1016/j.bbamcr.2006.09.015

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## Abstract Overexpression of ΔNp63 has been observed in a number of human cancers, suggesting a role for ΔNp63 in carcinogenesis. In the present study, we show that inhibition of glycogen synthase kinase‐3β (GSK‐3β) by lithium chloride (LiCl) elicited a stimulatory effect on ΔNp63 promoter activit