Glycation of lens proteins by the oxidation products of ascorbic acid
✍ Scribed by Simon H. Slight; Milton S. Feather; B.J. Ortwerth
- Book ID
- 113268043
- Publisher
- Elsevier Science
- Year
- 1990
- Tongue
- English
- Weight
- 709 KB
- Volume
- 1038
- Category
- Article
- ISSN
- 0167-4838
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Cataract is generally associated with the breakdown of the lens microarchitecture. Age-dependent chemical modifications and cross-linking of proteins are the major pathways for development of lens opacity. The specific alterations in lens proteins caused by glycation with four carbonyl metabolites,
## Abstract The effects of three dipeptides L‐phenylalanyl‐glycine, glycyl‐L‐phenylalanine, and aspartame (L‐aspartyl‐L‐phenylalanine, methyl ester) as inhibitors of the ascorbic acid‐induced modifications in lens proteins were studied. Their efficiency was compared to that of two known inhibitors—