Glutathione S-transferases (GSTT1 and GSTM1) genes polymorphisms and the treatment response and prognosis in Chinese patients with de novo acute myeloid leukemia

✍ Scribed by Zhijian Xiao; Lin Yang; Zefeng Xu; Yue Zhang; Liang Liu; Ling Nie; Lin Li; Jianxiang Wang; Yushu Hao

• Publisher: Elsevier Science
• Year: 2008
• Tongue: English
• Weight: 224 KB
• Volume: 32
• Category: Article
• ISSN: 0145-2126
• DOI: 10.1016/j.leukres.2007.10.010

✦ Synopsis

We investigated the prognostic significance of genetic polymorphism for glutathione S-transferase theta 1 (GSTT1) and glutathione S-transferase mu 1 (GSTM1) in 254 Chinese patients with de novo acute myeloid leukemia (AML) other than AML-M3. The early death rate after the initiation of chemotherapy was similar between the GSTT1+/GSTM1+ group and GSTT1-/GSTM1- group. The complete remission (CR) rate was higher in GSTM1+ group than in GSTM1- group (OR=1.88; P=0.03) after the first course of chemotherapy, and was higher in GSTT1+ group than in GSTT1- group (OR=2.20; P=0.02) after the second course of chemotherapy. Overall survival and disease-free survival of CR patients in GSTT1 and GSTM1 double present group was better than in GSTT1- and/or GSTM1-group (P=0.03 and 0.02, respectively). Our preliminary results warrant testing of a larger number of patients.