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Glutathione Modulation Changes the Penetration of N-[3H]methyl-N-nitro-N-nitrosoguanidine into Gastric Mucosa of Rats

โœ Scribed by Kjell K. Ovrebo; Asbjorn Svardal; Steinar Kvinnsland; Ketil Grong; Knut Svanes; Halfdan Sorbye

Book ID
111567254
Publisher
Springer US
Year
1999
Tongue
English
Weight
685 KB
Volume
44
Category
Article
ISSN
0163-2116

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โœ Frederick R. de Rubertis; Patricia A. Craven ๐Ÿ“‚ Article ๐Ÿ“… 1977 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 979 KB

The effects of N-methyl-N'-nitro-N-nitrosoguanidine (MNNG) on the guanylate cyclase (GC)-guanosine 3'5' monophosphate (cGMP) system of rat colonic mucosa were studied. MNNG (1 mM) increased colonic mucosal cGMP from 1.8 f 03 to 22.5 f 2.7 pmol/mg protein in 5 minutes. Increases in response to MNNG o

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We previously suggested that hydroxyl free radical (โ€ขOH) production may play a role in carcinogenesis induced by N-methyl-Nะˆ-nitro-N-nitrosoguanidine (MNNG). MNNGinduced gastric cancer in rats and human gastric carcinoma occur most often in the antral mucosa and rarely in the normal fundic mucosa. W