Glutathione 5-transferase and P-glycoprotein in multidrug resistant chinese hamster cells
โ Scribed by Rheem D. Medh; Vicram Gupta; Yin Zhang; Yogesh C. Awasthi; James A. Belli
- Book ID
- 115781401
- Publisher
- Elsevier Science
- Year
- 1990
- Tongue
- English
- Weight
- 694 KB
- Volume
- 39
- Category
- Article
- ISSN
- 0006-2952
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๐ SIMILAR VOLUMES
While P-glycoprotein (Pgp) and multidrug resistance-associated protein 1 (MRP1) are known to be important in acquired doxorubicin resistance, the role of glutathione S-transferases (GST) remains unclear. Our study assessed roles of these 3 factors in a human drug-sensitive carcinoma cell line (HEp2)
## Abstract We have previously shown that very high levels of hypersensitivity to several resistance modifiers are correlated with increasing multidrug resistance in a series of Chinese hamster ovary cell lines. We have now selected a new member of the series which is an exception to this correlati