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Glutamine-stimulated modification and degradation of glutamine synthetase in hepatoma tissue culture cells

โœ Scribed by Arad, Gila; Freikopf, Aliza; Kulka, Richard G.


Book ID
121940689
Publisher
Elsevier Science
Year
1976
Tongue
English
Weight
970 KB
Volume
8
Category
Article
ISSN
0092-8674

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Glutamine-stimulated modification and de
โœ Arad, Gila; Freikopf, Aliza; Kulka, Richard G. ๐Ÿ“‚ Article ๐Ÿ“… 1976 ๐Ÿ› Elsevier Science ๐ŸŒ English โš– 970 KB

Effects of glutamine on glutamine synthetase (GS) activity of hepatoma tissue culture (HTC) cells were studied with the aid of a specific goat anti-rat GS serum. lmmunodiffusion and immunoelectrophoretic tests show that rat liver GS and HTC cell GS are immunologically similar but not identical. lmmu

Glutamine regulates glutamine synthetase
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Metabolite control of glutamine synthetase expression (by glutamine) was studied in L6 skeletal muscle cells. Depletion of glutamine from the culture medium for 24 hours resulted in a 3-4-fold increase in glutamine synthetase activity. This effect was blocked by cycloheximide but not by actinomycin