Glutamine, myo-inositol, and brain edema in acute liver failure

✍ Scribed by J Cordoba

• Publisher: John Wiley and Sons
• Year: 1996
• Tongue: English
• Weight: 135 KB
• Volume: 23
• Category: Article
• ISSN: 0270-9139
• DOI: 10.1002/hep.510230557

✦ Synopsis

CORRESPONDENCE 1291 a predictor of subsequent response to interferon-a therapy in Japthe study of Nossbaum et al. 3 ), type 1b HCV was found anese patients with chronic hepatitis C. J Med Virol 1994;44:410more frequently in older patients and was more likely 414. to be associated with acquisition via blood transfusion 7. Nousbaum JB, Pol S, Nalpas B, Landais P, Berthelot P, Bre ´chot or by unknown means rather than via intravenous drug C, Collaborative Study Group. Hepatitis C virus type 1b (II) infection in France and Italy. Ann Intern Med 1995;122:161-168. use. Why should these differences exist if the viruses 8. Simmonds P. Varibility of hepatitis C virus. HEPATOLOGY 1995; are biologically identical? More importantly, if, as these 21:570-583.

epidemiological data would suggest, types 1a and 1b HCV are not biologically identical, what is the mechanism by which these observed differences arise? I Reply: strongly believe this observed phenomenon of molecular Darwinism is a critical clue to the understanding The careful study of Pawlotsky et al. has led them to the behavior of chronic viral infections and holds the believe types 1a and 1b HCV are pathogenically similar key to novel and effective forms of antiviral chemotherand that future studies should include sufficient cases apy (Sallie R, manuscripts submitted and in preparato allow reliable statistical analysis using multivariate tion). statistical analysis without pooling subtypes. While I RICHARD SALLIE, M.D., F.R.A.C.P. fully agree with this suggestion, and have argued in Department of Medicine print that definitive dissection of any important University of Western Australia differences between hepatitis C genotypes and sub-Nedlands, Perth, Australia types will require analysis of similarly collected data obtained from many centers, 1 I do not believe that the