The production of L-glutamic acid with Corynebacterium glutamicum under biotin limitation was studied. Assuming a formal type of cell maturation, an adequate formal kinetic model was developed. This model includes growth. dependent on hiotin. and uses the same retention term for describing the lag p
Glutamic acid production with gel-entrapped Corynebacterium glutamicum
β Scribed by Wlodzimierz Slowinski; Stanley E. Charm
- Publisher
- John Wiley and Sons
- Year
- 1973
- Tongue
- English
- Weight
- 260 KB
- Volume
- 15
- Category
- Article
- ISSN
- 0006-3592
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The study was aimed at evaluating the extent of flux control exercised by the amino acid excretion step on the glutamate production flux in C. glutamicum 2262 strain that is induced for glutamate excretion by an upward temperature shift. Cells initially induced to excrete glutamate were cultivated a
To give clues about the respective importance of phosphoenolpyruvate carboxylase (PEPc) and pyruvate carboxylase (Pc) in Corynebacterium glutamicum metabolism during a temperature triggered glutamic acid fermentation, PEPc activity was genetically amplified and Pc activity was suppressed by biotin l
## Abstract Since the 1950s when __Micrococcus glutamicus__ later renamed __Corynebacterium glutamicum__ was discovered, the production of amino acids by fermentative methods has become an important aspect of industrial microbiology. Numerous studies to understand and improve the metabolic conditio