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Glutamic acid as a new linker for attachment of alcohols to solid support

✍ Scribed by Gilles Subra; Muriel Amblard; Jean Martinez

Publisher
Elsevier Science
Year
2002
Tongue
French
Weight
134 KB
Volume
43
Category
Article
ISSN
0040-4039

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πŸ“œ SIMILAR VOLUMES

A novel linker for the attachment of alc
A novel linker for the attachment of alcohols to solid supports
✍ Gerd BΓΆhm; James Dowden; David C. Rice; Ian Burgess; Jean-Francois Pilard; Bened πŸ“‚ Article πŸ“… 1998 πŸ› Elsevier Science 🌐 French βš– 263 KB

A novel tinker for the immobilisation of alcohols on solid support is described. This linker can be cleaved either enzymaticaUy using penicillin amidase, or by very mild acid hydrolysis using 10% TFA.

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A simple linker has been developed for the attachment of ahtehyde fimctionality. The aldehyde substrate is condensed with a support-bound serine or threonine to give an oxazolidine. The oxazolidine linker is stable to the conditions of Fntoc peptide synthesis, inchtding TFA treatment, but is cleaved

4-(3-Hydroxy-4-methylpentyl)phenylacetic
4-(3-Hydroxy-4-methylpentyl)phenylacetic acid as a new linker for the solid phase synthesis of peptides with Boc chemistry
✍ Katri Rosenthal; Mikael Erlandsson; Anders UndΓ©n πŸ“‚ Article πŸ“… 1999 πŸ› Elsevier Science 🌐 French βš– 200 KB

The anchoring the first amino acid in Boc chemistry to a 4-(3-hydroxy-4methylpentyl)phenylacetic acid linker is described and compared to the conventional Pam resin. The peptidyl-4-(4-methyl-3-pentoxy)phenylacetamide linkage is slightly more stable to TFA than the Pam linker but in contrast to the P