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Glutamate up-regulates P-glycoprotein expression in rat brain microvessel endothelial cells by an NMDA receptor-mediated mechanism

✍ Scribed by Hao-Jie Zhu; Guo-Qing Liu

Book ID
116717443
Publisher
Elsevier Science
Year
2004
Tongue
English
Weight
208 KB
Volume
75
Category
Article
ISSN
0024-3205

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## Abstract A major concern regarding the chronic administration of antiretroviral drugs is the potential for induction of drug efflux transporter expression (i.e., P‐glycoprotein, P‐gp) at tissue sites that can significantly affect drug distribution and treatment efficacy. Previous data have shown