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Glucuronidation of the mycotoxins alternariol and alternariol-9-methyl ether in vitro: chemical structures of glucuronides and activities of human UDP-glucuronosyltransferase isoforms

✍ Scribed by E. Pfeiffer; C. Schmit; B. Burkhardt; M. Altemöller; J. Podlech; M. Metzler

Book ID
107664816
Publisher
Springer-Verlag
Year
2008
Tongue
English
Weight
169 KB
Volume
25
Category
Article
ISSN
0178-7888

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## Abstract The __Alternaria__ toxins alternariol (AOH; 3,7,9‐trihydroxy‐1‐methyl‐6__H__‐benzo[__c__]chromen‐6‐one) and alternariol methyl ether (AME, 3,7‐dihydroxy‐9‐methoxy‐1‐methyl‐6__H__‐benzo[__c__]chromen‐6‐one) are common contaminants of food and feed, but their oxidative metabolism in mamma

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## Abstract Glucuronidation constitutes an important pathway in the phase II metabolism of the mycotoxin zearalenone (ZEN) and the growth promotor α‐zearalanol (α‐ZAL, zeranol), but the enzymology of their formation is yet unknown. In the present study, ZEN, α‐ZAL and four of their major phase I me