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Absorption and metabolism of the mycotoxins alternariol and alternariol-9-methyl ether in Caco-2 cells in vitro

✍ Scribed by Britta Burkhardt; Erika Pfeiffer; Manfred Metzler

Book ID
107664836
Publisher
Springer-Verlag
Year
2009
Tongue
English
Weight
205 KB
Volume
25
Category
Article
ISSN
0178-7888

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Novel oxidative in vitro metabolites of
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## Abstract The __Alternaria__ toxins alternariol (AOH; 3,7,9‐trihydroxy‐1‐methyl‐6__H__‐benzo[__c__]chromen‐6‐one) and alternariol methyl ether (AME, 3,7‐dihydroxy‐9‐methoxy‐1‐methyl‐6__H__‐benzo[__c__]chromen‐6‐one) are common contaminants of food and feed, but their oxidative metabolism in mamma

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## Abstract **Scope:** Monohydroxylation of alternariol (AOH) and alternariol‐9‐methyl ether (AME) has previously been reported as a prominent metabolic route under cell‐free conditions. This pathway gives rise to several catechol metabolites and may therefore be of toxicological relevance. **Meth